Patch containing isosorbide dinitrate

Details Patch containing isosorbide dinitrate Patch containing isosorbide dinitrate

A - Human Necessities

61

K

A61K 31/34 (2006.01) A61K 9/70 (2006.01)

Patent

CA 2248167

The present invention relates to an isosorbide dinitrate- containing patch, in which an adhesive layer comprising an adhesive composition is formed on a flexible support, and the adhesive composition consists of an acrylic-based adhesive (A), a polyvinyl acetate-based adhesive (B), a plasticizing component (C) and isosorbide dinitrate (D), and satisfies the following weight ratios (1) through (3) of each of the components: (1) A:B = 70:30 to 10:90, (2) the weight ratio of the component C based on the adhesive composition is 10 to 40% by weight, and (3) the weight ratio of the component D based on the adhesive composition is 20 to 35% by weight. Provided is a patch excellent in percutaneous absorption, handleability, resistance to skin irritation, sustained release, adhesivity, etc.

L'invention porte sur un timbre transdermique contenant du dinitrate d'isosorbide et fait d'un substrat souple revêtu d'une couche d'un ensemble adhésif autocollant se composant d'un adhésif autocollant acrylique (A), d'un adhésif autocollant polyvinylique (B), d'un plastifiant (C), et de dinitrate d'isosorbide, et dont les proportions pondérales satisfont aux exigences 1 à 3 suivantes: 1) A : B = 70 30 à 10 : 90; 2) le composant C représente de 10 à 40 % en poids; 3) le composant (D) représente de 20 à 35 % en poids. Ce timbre est excellent en matière d'absorption percutanée, de maniabilité, de prévention des irritations de la peau, de persistance de la libération, de collant, et d'autres propriétés.

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