A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/34 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2184389
The present invention provides an ISDN-containing patch that causes minimal occurrence of skin rash and has excellent percutaneous absorption and adhesive strength. The present invention discloses an isosorbide dinitrate-containing patch comprising: an adhesive layer formed on a flexible support, wherein said layer comprises an adhesive composition containing adhesive and isosorbide dinitrate, the adhesive being composed of silicone-based adhesive (A) and polyvinyl acetate-based adhesive (B), their weight ratio being A:B = 85:15 to 15:85, and the weight ratio of isosorbide dinitrate (C) to the adhesives (A+B) being (A+B):C = 90:10 to 60:40.
Timbre renfermant du dinitrate d'isosorbide, pouvant diminuer l'apparition d'une éruption cutanée, et présentant une absorbabilité percutanée et un pouvoir adhésif excellents. On produit ce timbre en formant sur un support souple une couche adhésive comportant une composition adhésive renfermant une colle de contact et du dinitrate d'isosorbide. La colle de contact est un mélange d'une colle au silicone (A) et d'une colle polyvinylique (B) selon un rapport pondéral (A/B) allant de 85/15 à 15/85. Le rapport pondéral entre le mélange (A+B) et le dinitrate est compris entre 90/10 et 60/40.
Fujii Takao
Furuya Minoru
Iwata Makoto
Ohe Michisuke
Mcfadden Fincham
Teijin Limited
LandOfFree
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