Pathogenic and commensal vaccine antigens

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/31 (2006.01) A61K 39/095 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)

Patent

CA 2441551

The invention provides methods of screening commensal and pathogenic bacteria for previously unidentified vaccine antigens, based upon identifying polypeptide antigens that bind to sera raised against commensal bacterial proteins. Also provided are vaccine compositions and methods of preparing vaccine compositions comprising the antigens identified by the screening methods. Antigens and uses thereof are also described.

Cette invention concerne des méthodes permettant de cribler des bactéries commensales et pathogènes pour des antigènes vaccinaux non identifiés jusqu'alors. Ces méthodes consistent à identifier des antigènes polypeptidiques se liant à des sérums contre des protéines bactériennes commensales. L'invention concerne également des compositions de vaccins renfermant les antigènes identifiés par criblage. Sont également décrits des antigènes et leurs utilisations.

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