Pathological tissue detection and treatment employing...

Details Pathological tissue detection and treatment employing... Pathological tissue detection and treatment employing...

C - Chemistry, Metallurgy

09

B

C09B 23/16 (2006.01) A61K 41/00 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01) A61K 51/04 (2006.01) C07D 209/60 (2006.01)

Patent

CA 2463906

Novel tumor specific phototherapeutic and photodiagnostic agents are disclosed. The compounds consist of a carbocyanine dye for visualization, photosensitizer for photodynamic treatment, and tumor receptor-avid peptide for site-specific delivery of the probe and phototoxic agent to diseased tissues. A combination of these elements takes full advantage of the unique and efficient properties of each component for an effective patient care management.

Nouveaux agents photothérapeutiques et photodiagnostiques spécifiques des tumeurs. Les composés selon la présente invention contiennent un colorant carbocyanine pour la visualisation, un photosensibilisant pour le traitement photodynamique et un peptide attiré par les récepteurs tumoraux en vue de l'acheminement, spécifique à un site, de la sonde et de l'agent phototoxique vers les tissus malades. Une combinaison de ces éléments tire pleinement profit des propriétés uniques et efficaces de chaque constituant pour une gestion efficace de la prise en charge du patient.

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