Pathologically modified myocardial cell, production and use...

Details Pathologically modified myocardial cell, production and use... Pathologically modified myocardial cell, production and use...

A - Human Necessities

61

K

A61K 35/34 (2006.01) C12N 5/10 (2006.01) G01N 33/50 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2395228

The invention relates to a pathologically modified myocardial cell which can be produced from healthy cardiac tissue by providing or isolating at least one healthy myocardial cell, by stimulating said isolated myocardial cell using the appropriate hormones, hormone analogues and/or zytokines and by detecting the pathologically modified myocardial cell(s) by localising at least one signal molecule. The invention also relates to a method for producing said pathologically modified myocardial cell and to the use thereof, including a method for detecting or identifying cardioactive substances.

L'invention concerne une cellule du myocarde pathologiquement modifiée produite à partir d'un tissu cardiaque sain par préparation ou isolation d'au moins une cellule du myocarde saine, par stimulation de la cellule du myocarde isolée par des hormones, analogues d'hormones et/ou cytokines appropriés; par détection de la ou des cellule(s) du myocarde pathologiquement modifiée(s) par détermination de la localisation d'au moins une molécule-signal. L'invention concerne également un procédé de production de cette cellule du myocarde pathologiquement modifiée et son utilisation, ainsi qu'un procédé permettant de détecter ou d'identifier des substances cardioactives.

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