C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/867 (2006.01) A01K 67/00 (2006.01) A61K 48/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) C12N 7/01 (2006.01) C12N 15/00 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2668285
Systems for pathotropic (disease-seeking) targeted gene delivery are provided, including viral particles with extremely high titers. In particular, the viral particles are engineered to specifically deliver therapeutic or diagnostic agents to a disease site, such as cancer metastic sites. Personalized dosing regimens are also provided to treat diseases such as cancer efficaciously with reduced adverse side effects.
Cette invention concerne des systèmes pour introduction de gènes par ciblage pathotropique (recherche de maladies), y compris de particules virales à titres extrêmement élevés. En particulier, les particules virales sont conçues pour introduire spécifiquement des agents thérapeutiques ou diagnostiques dans un site pathologique, tel qu'un site métastatique d'un cancer. Des schémas posologiques personnalisés permettent de traiter efficacement des maladies telles qu'un cancer avec moins d'effets secondaires.
Gordon Erlinda M.
Hall Frederick L.
Levy John P.
Reed Rebecca A.
Epeius Biotechnologies Corporation
Smart & Biggar
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