Patient-specific immunoadsorbents for extracorporal...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 35/14 (2006.01) A61M 1/36 (2006.01) A61M 1/38 (2006.01) G01N 33/547 (2006.01)

Patent

CA 2234088

The invention relates to the production of multiple-application patient- specific immunoadsorbents which can be used for extracorporal apheresis in patients suffering from disorders caused by dysregulation of the immune system. Conventional methods are used to isolate the immune complexes from the patient's blood and appropriate methods are applied to separate the immune complexes into antigens and antibodies. The antigens and antibodies thus reactivated are coupled individually or as a mixture covalently to suitable carriers which are used as immunoadsorbents for the patient from whom the immune complexes originate. This facilitates production of specific immunoadsorbents even for patients suffering from rare auto-immune diseases.

L'invention concerne la production d'immuno-adsorbants spécifiques à chaque patient et à usage multiple. Lesdits immuno-adsorbants peuvent être utilisés pour l'aphérèse extracorporelle de patients qui souffrent de maladies dues à un dysfonctionnement du système immunitaire. Grâce à des procédés traditionnels, on isole, du sang du patient concerné, les complexes immuns qui sont séparés en antigènes et anticorps par des méthodes appropriées. Les antigènes et anticorps ainsi réactivés sont couplés de façon covalente, individuellement ou sous forme de mélange, à des substrats adéquats qui sont utilisés comme immuno-adsorbants pour le patient dont proviennent les complexes immuns. On peut ainsi produire des immuno-adsorbants à effet spécifique même pour les patients qui souffrent de maladies autoimmunes rares.

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