C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) C12N 9/22 (2006.01) G01N 33/50 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2385425
The present invention is directed to novel polypeptides, nucleic acids and related molecules which have an effect on or are related to the cell cycle. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided by the present invention are methods for identifying novel compositions which mediate cell cycle bioactivity, and the use of such compositions in diagnosis and treatment of disease.
La présente invention concerne de nouveaux polypeptides, acides nucléiques et molécules qui y sont liées, qui affectent le cycle cellulaire ou qui y sont liés. Elle concerne également des vecteurs et des cellules hôtes comprenant ces séquences d'acides nucléiques, des molécules polypeptidiques chimères comprenant les polypeptides de l'invention, fusionnés avec des séquences polypeptidiques hétérologues, des anticorps qui se lient aux polypeptides de la présente invention et des procédés pour produire les polypeptides de l'invention. Elle concerne enfin des procédés pour identifier de nouvelles compositions impliquées dans la bioactivité du cycle cellulaire et l'utilisation de ces compositions dans le diagnostic et le traitement de maladies.
Huang Betty
Luo Ying
Rigel Pharmaceuticals Inc.
Smart & Biggar
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