Pd-1, a receptor for b7-4, and uses therefor

Details Pd-1, a receptor for b7-4, and uses therefor Pd-1, a receptor for b7-4, and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/06 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2383456

The invention identifies PD-1 as a receptor for B7-4. B7-4 can inhibit immune cell activation upon binding to an inhibitory receptor on an immune cell. Accordingly, the invention provides agents for modulating PD-1, B7-4, and the interaction between B7-4 and PD-1 in order to modulate a costimulatory or an inhibitory signal in an immune cell resulting in modulation of the immune response.

Dans cette invention, on a identifié PD-1 comme étant un récepteur de B7-4. B7-4 peut inhiber l'activation des cellules immunitaires après liaison à un récepteur inhibiteur sur une cellule immunitaire. L'invention concerne également des agents pour moduler PD-1, B7-4 et l'interaction entre B7-4 et PD-1 visant à moduler un signal de co-stimulation ou d'inhibition dans une cellule immunitaire, ce qui a pour effet de moduler la réponse immunitaire.

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