Pd-l2 molecules: novel pd-1 ligands and uses therefor

Details Pd-l2 molecules: novel pd-1 ligands and uses therefor Pd-l2 molecules: novel pd-1 ligands and uses therefor

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2414331

The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.

L'invention concerne des molécules d'acides nucléiques isolées appelées molécules d'acides nucléiques PD-L2, codant de nouvelles molécules associées à B7, ces dernières molécules étant des ligands de PD-1. L'invention concerne également des molécules d'acides nucléiques antisens, des vecteurs d'expression de recombinaison contenant des molécules d'acides nucléiques PD-L2, des cellules hôtes dans lesquelles les vecteurs d'expression ont été introduits, ainsi que des animaux transgéniques non-humains dans lesquels une gène PD-L2 à été introduit ou interrompu. L'invention concerne également des polypeptides PD-L2 isolés, des protéines de fusion, des peptides antigènes, et des anticorps anti-PD-L2. L'invention concerne également des procédés destinés à favoriser ou inhiber l'interaction entre PD-L2 et PD-1. L'invention concerne également des procédés de diagnostic et de traitement faisant intervenir des compositions selon l'invention.

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