C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/44 (2006.01) A61K 31/00 (2006.01) A61P 13/00 (2006.01)
Patent
CA 2623657
The invention provides pharmacological compositions comprising PDE-5 and PDE-4 inhibitors, alone or in combination, for the treatment of urological disorders comprising Benign Prostate Hyperplasia (BPH), Lower Urinary Tract Symptoms (LUTS) and in particular irritative symptoms caused by BPH-induced bladder outlet obstruction (BOO). The invention also provides methods of screening for such PDE-5 and PDE-4 inhibitors for use, alone and in combination, in the preparation of medicaments for the treatment of said urological disorders.
L'invention concerne des compositions pharmaceutiques contenant des inhibiteurs PDE-5 et PDE-4, seuls ou en combinaison, pour traiter des troubles urinaires comprenant l'hyperplasie bénigne de la prostate (BPH), les symptômes du bas appareil urinaire (LUTS) et en particulier les symptômes d'irritation causés par l'obstruction sous vésicale (BOO) induite par le BPH. La présente invention porte également sur des procédés de criblage de ces inhibiteurs PDE-5 et PDE-4 pour leur utilisation, seuls ou en combinaison, dans la préparation de médicaments pour le traitement desdits troubles urinaires.
Huetter Joachim
Sandner Peter
Tinel Hanna
Ulbrich Ernst
Bayer Healthcare Ag
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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