Pde iv inhibiting compounds, compositions and methods of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 213/89 (2006.01) A61K 31/44 (2006.01) A61P 11/06 (2006.01) C07D 213/30 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2364653

The invention encompasses compounds of Formula (I) useful in the treatment of diseases, including asthma, by raising the level of cyclic adenosine-3',5'- monophosphate (cAMP) through the inhibition of phosphodiesterase IV (PDE IV). The invention also encompasses certain pharmaceutical compositions and methods for treatment of diseases by inhibition of PDE IV, resulting in an elevation of cAMP, comprising the use of compounds of Formula (I).

La présente invention concerne des composés représentés par la formule (I) utilisés dans le traitement de maladies, notamment de l'asthme, et permettant d'augmenter le niveau d'adénosine-3',5'-monophosphate (cAMP) cyclique par inhibition de phosphodiestérase IV (PDE IV). L'invention concerne également certaines compositions pharmaceutiques et des méthodes de traitement de maladies par inhibition de PDE IV avec, pour conséquence, une hausse de cAMP, méthodes dans lesquelles sont utilisés les composés représentés par la formule (I).

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