Pde10 inhibitors and related compositions and methods

Details Pde10 inhibitors and related compositions and methods Pde10 inhibitors and related compositions and methods

C - Chemistry, Metallurgy

07

C

C07C 251/86 (2006.01) A61K 31/16 (2006.01) A61K 31/33 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) C07D 213/30 (2006.01) C07D 215/14 (2006.01) C07D 231/12 (2006.01) C07D 249/06 (2006.01) C07D 265/36 (2006.01) C07D 275/02 (2006.01) C07D 295/096 (2006.01) C07D 317/62 (2006.01) C07D 319/18 (2006.01) C07D 333/56 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2733378

Compounds that inhibit PDE10 are disclosed that have utility in the treatment of a variety of conditions, including (but not limited to) psychotic, anxiety, movement disorders and/or neurological disorders such as Parkinson's disease, Huntington's disease, Alzheimer's disease, encephalitis, phobias, epilepsy, aphasia, Bell's palsy, cerebral palsy, sleep disorders, pain, Tourette's syndrome, schizophrenia, delusional disorders, drug-induced psychosis and panic and obsessive-compulsive disorders. Pharmaceutically acceptable salts, stereoisomers, solvates and prodrugs of the compounds are also provided. Also disclosed are compositions containing a compound in combination with a pharmaceutically acceptable carrier, as well as methods relating to the use thereof for inhibiting PDE10 in a warm-blooded animal in need of the same.

La présente invention concerne des composés qui inhibent PDE10 et qui ont une utilité dans le traitement de différentes pathologies, comprenant (mais non limitées à) des troubles psychotiques, danxiété, du mouvement et/ou des troubles neurologiques tels que la maladie de Parkinson, la maladie de Huntington, la maladie dAlzheimer, lencéphalite, les phobies, lépilepsie, laphasie, la paralysie faciale périphérique de Bell, l'infirmité motrice cérébrale, des troubles du sommeil, la douleur, le syndrome de Tourette, la schizophrénie, les troubles délirants, une psychose dorigine médicamenteuse et des troubles de panique et obsessionnels compulsifs. La présente invention concerne en outre des sels pharmaceutiquement acceptables, des stéréo-isomères, des solvates et des promédicaments des composés. La présente invention concerne en outre des compositions contenant un composé en combinaison avec un véhicule pharmaceutiquement acceptable, ainsi que des procédés concernant lutilisation de celles-ci pour linhibition de PDE10 chez un animal à sang chaud nécessitant celle-ci.

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