C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61P 9/00 (2006.01) A61P 15/00 (2006.01)
Patent
CA 2466824
The invention relates to PDE9 inhibitors for treating cardiovascular disorders. Preferred PDE9 inhibitors are compounds of formula (I) wherein R1 is H or C1-6 alkyl, wherein R1 is attached to either N1 or N2; R2 is C1-6 alkyl optionally substituted by hydroxy or alkoxy; C3-7 cycloalkyl optionally substituted by alkyl, hydroxy or alkoxy; a saturated 5-6-membered heterocycle optionally substituted by alkyl, hydroxy or alkoxy; het1 or Ar1; R3 is C1-6 alkyl optionally substituted by 1 or 2 groups independently selected from: Ar2; C3-7 cycloalkyl optionally substituted by C1-6 alkyl; OAr2; SAr2; Sar2; NHC(O)C1-6 alkyl; het2; xanthene; and naphthalene (I).
L'invention se rapporte à des inhibiteurs PDE9 utilisés dans le traitement des troubles cardio-vasculaires. Des inhibiteurs PDE9 préférés sont des composés représentés par la formule I dans laquelle R?1¿ est H ou C¿1-6 ?alkyle, R?1¿ étant fixé à N?1¿ ou N?2¿ ; R?2 ¿est C¿1-6?alkyle facultativement substitué par hydroxy ou alkoxy ; C¿3-7 ?cycloalkyle facultativement substitué par alkyle, hydroxy ou alkoxy ; un hétérocycle à 5 ou 6 éléments saturé facultativement substitué par alkyle, hydroxy ou alkoxy ; het?1¿ ou Ar?1¿ ; R?3¿ est C¿1-6 ?alkyle facultativement substitué par un ou deux groupes indépendamment choisis parmi : Ar?2¿ ; C¿3-7 ?cycloalkyle facultativement substitué par C¿1-6 ?alkyle ; OAr?2¿ ; SAr?2¿ ; NHC(O)C¿1-6 ?alkyle ; het?2¿ ; xanthène ; et naphtalène.
Deninno Michael Paul
Hughes Bernadette
Kemp Mark Ian
Palmer Michael John
Wood Anthony
Pfizer Inc.
Smart & Biggar
LandOfFree
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