Pdf inhibitors

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/04 (2006.01) A61K 31/41 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 31/04 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01) C07D 417/04 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07D 491/04 (2006.01) C07D 498/04 (2006.01)

Patent

CA 2629148

The invention relates to novel compounds that are inhibitors of peptidyl deformylase (PDF). The compounds are useful as antimicrobials and antibiotics. The compounds of the invention display selective inhibition of peptidyl deformylase versus other metalloproteinases such as MMPs. Methods of preparation and uses of the compounds are also disclosed.

La présente invention concerne de nouveaux composés qui sont des inhibiteurs de peptidyl déformylase (PDF). Les composés sont utiles en tant qu'antimicrobiens et antibiotiques. Les composés de l'invention présentent une inhibition sélective de la peptidyl déformylase par rapport à d'autres métalloprotéases telles que les MMP. La présente invention concerne en outre des procédés de préparation et des utilisations des composés.

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