Pdgf receptor kinase inhibitory compounds and compositions,...

C - Chemistry – Metallurgy – 07 – D

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C07D 241/36 (2006.01) A01N 43/58 (2006.01) C07D 241/42 (2006.01) C07D 409/04 (2006.01) C07D 471/00 (2006.01) C07D 487/04 (2006.01)

Patent

CA 2312749

PDGF receptor kinase inhibitory compounds of the quinoxaline family, methods for their synthesis and containment in slow release pharmaceutical preparations, and their use for treatment of proliferative malignant and non- malignant diseases or disorders by local or systemic application. A compound according to the invention includes a tyrphostin of general formula (I), wherein R1 and R2 are each independently selected from the group consisting of alkyl, alkoxy, halogen, nitro and amine and Ar is selected from the group consisting of phenyl, ferrocene, thiophene, furane, pyrrole, indole, thiazole, imidazole and pyridine.

La présente invention concerne des composés PDGF inhibiteurs du récepteur de la kinase et faisant partie de la famille des quinoxalines, leurs procédés de synthèse et de confinement par des préparations pharmaceutiques à libération lente, ainsi que leur utilisation dans le traitement des maladies ou des affections évolutives malignes et bénignes par une application générale ou locale. Un composé élaboré selon cette invention renferme un tyrphostin représenté par la formule générale (I), dans laquelle R1 et R2 sont sélectionnés individuellement dans le groupe constitué par alkyl, alcoxy, halogène, nitro et amine, Ar étant sélectionné dans le groupe constitué par phényle, ferrocène, thiophène, furane, pyrrole, indol, thiazol, imidazol et pyridine.

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