Pdk4 as marker for ppardelta modulation

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2560686

The present invention relates to the use of PDK4 as biomarker for PPAR delta activity, and to methods of diagnosing a disease linked to dysregulation of PPARdelta activity such as for example dyslipidemia, obesity or insulin resistance, methods of monitoring the treatment of patients suffering from a disease linked to dysregulation of PPARdelta activity, and methods of identifying compounds which modulate PPARdelta activity.

La présente invention concerne l'utilisation de PDK4 en tant que biomarqueur pour une activité de PPARdelta, des procédés pour diagnostiquer une maladie liée à un dérèglement de l'activité de PPARdelta, par exemple une dyslipidémie, une obésité ou une résistance à l'insuline, des procédés pour surveiller le traitement de patients souffrant d'une maladie liée à un dérèglement de l'activité de PPARdelta, ainsi que des procédés pour identifier des composés qui modulent l'activité de PPARdelta.

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