Pearlescent film coating systems and substrates coated...

A - Human Necessities – 61 – K

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Details

A61K 9/36 (2006.01) A23L 1/48 (2006.01) A61J 3/06 (2006.01) A61K 9/28 (2006.01) B05D 7/24 (2006.01) C09D 5/36 (2006.01) C09D 101/00 (2006.01) C09D 101/26 (2006.01) C09D 101/28 (2006.01)

Patent

CA 2513532

The present invention is directed to film coating systems for use on oral dosage forms such as compressed tablets and orally-ingestible substrates which have improved pearlescent qualities. The film coating systems can be applied either directly to a substrate or after the substrate has been coated with a subcoat. In preferred aspects, the pearlescent film coating is prepared as a dry powder mixture containing a cellulosic polymer, a detackifier, a gloss enhancer, and a pearlescent pigment. Film coating compositions containing an aqueous suspension of the powder mixtures, methods of applying the coatings to substrates and the coated substrates are also disclosed.

L'invention concerne des systèmes d'enrobage par film à utiliser sur des formes galéniques orales, telles que des tablettes comprimées et des substrats pouvant être ingérés par voie orale, possédant des qualités perlées améliorées. Les systèmes d'enrobage par film peuvent être appliqués soit directement sur un substrat, soit après l'enrobage du substrat au moyen d'un sous-enrobage. Dans des modes de réalisation préférés, l'enrobage par film perlé est préparé sous la forme d'un mélange de poudre sèche renfermant un polymère cellulosique, un anti-adhésif, un agent améliorant la brillance et un pigment perlé. L'invention concerne également des compositions d'enrobage par film renfermant une suspension aqueuse des mélanges de poudre, des procédés d'application des enrobages sur des substrats et les substrats enrobés.

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