Peg-functional nucleic acid conjugate

Details Peg-functional nucleic acid conjugate Peg-functional nucleic acid conjugate

C - Chemistry, Metallurgy

08

G

C08G 81/00 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07H 21/04 (2006.01) C08G 65/329 (2006.01)

Patent

CA 2562938

A conjugate of functional oligonucleotide and poly(ethylene oxide); a polyion complex from this conjugate and a cationic polymer; and a micelle thereof. This micelle achieves stabilization of the oligonucleotide in animal cells and enhances its specific binding capability to target gene.

Conjugué d'oligonucléotide fonctionnel et de poly(oxyde d'éthylène) ; complexe de polyion à partir de ce conjugué et polymère cationique ; et micelle de celui-ci. Cette micelle parvient à réaliser la stabilisation de l'oligonucléotide dans des cellules animales et augmente sa capacité à lier de façon spécifique un gène cible.

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