C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/00 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) A61K 47/48 (2006.01) C07K 14/00 (2006.01) C07K 16/00 (2006.01) C08B 15/06 (2006.01) C08B 30/18 (2006.01) C08B 37/00 (2006.01) C08F 8/30 (2006.01)
Patent
CA 2110543
ABSTRACT The present invention provides methods and compounds for modifying polypeptides with PEG or other water-soluble organic polymers. Novel water- soluble polymer reagents are provided for. The water-soluble polymer reagents of the subject invention include hydrazine, hydrazine carboxylate, semicarbazide, thiosemicarbazide, carbonic acid dihydrazide, carbazide, thiocarbazide, and arylhydrazide derivatives as well as oxylamine derivatives of water-soluble organic polymers, such as polyethylene glycol, polypropylene glycol, polyoxyethylated polyol, heparin, heparin fragments, dextran, polysaccharides, polyamino acids, and polyvinyl alcohol. Also provided for, are polypeptides of interest derivatized by the subject water-soluble polymer reagents. Kits for modifying polypeptides with the subject water-soluble polymer reagents are also provided.
Ortho Pharmaceutical Corporation
Swabey Ogilvy Renault
LandOfFree
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