Peg modified exendin or exendin analog and compositions and...

Details Peg modified exendin or exendin analog and compositions and... Peg modified exendin or exendin analog and compositions and...

C - Chemistry, Metallurgy

07

K

C07K 14/575 (2006.01) A61K 38/22 (2006.01) A61K 47/48 (2006.01) A61P 3/10 (2006.01) C07K 17/06 (2006.01) C07K 17/08 (2006.01)

Patent

CA 2666182

Exendins or exendin analogs modified by one or more PEG derivatives that may be linked to one or more amino acids of the exendins or exendin analogs are provided. The PEG derivatives may have branched structure set forth in any one of formulas I-IV. Compositions including the PEG derivative modified exendin or exendin analog, methods of making or administering the modified exendin or exendin analog, and various uses thereof are also provided.

L'invention concerne des exendines ou des analogues d'exendine modifié(e)s par un ou plusieurs dérivés de PEG pouvant être liés à un ou plusieurs acides aminés des exendines ou des analogues d'exendine. Les dérivés de PEG peuvent présenter une structure ramifiée décrite dans l'une quelconque des formules I à IV. L'invention concerne également des compositions contenant les exendines ou les analogues d'exendine modifié(e)s par les dérivés de PEG. Elle concerne en outre des méthodes de production ou d'administration des exendines ou des analogues d'exendine modifié(e)s, ainsi que leurs diverses utilisations.

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