Peg-urate oxidase conjugates and use thereof

Details Peg-urate oxidase conjugates and use thereof Peg-urate oxidase conjugates and use thereof

C - Chemistry, Metallurgy

12

N

C12N 9/06 (2006.01) A61K 38/44 (2006.01) A61K 47/48 (2006.01) C12N 9/96 (2006.01)

Patent

CA 2338665

A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average molecular weight between about 5 kDa and 100 kDa. The resulting PEG-uricase conjugates are substantially non- immunogenic and retain at least 75 % of the uricolytic activity of the unmodified enzyme.

L'invention concerne une urate oxydase (uricase), naturelle ou recombinée, couplée de manière covalente à du poly(éthylène glycol) ou poly(éthylène oxyde) (tous deux dénommés PEG), 2 à 10 brins, en moyenne, de PEG étant conjugués à chaque sous-unité uricase, et le poids moléculaire moyen de PEG étant compris entre environ 5 kDa et 100 kDa. Les conjugués PEG-uricase résultants sont sensiblement non immunogènes et conservent au moins 75 % de l'activité uricolytique de l'enzyme non modifiée.

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