C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 25/28 (2006.01) C12N 15/13 (2006.01)
Patent
CA 2675847
A method to treat conditions associated with Aß peptide activity both prophylactically and therapeutically is described. The method employs humanized antibody fragments that specifically bind human Aß peptide between amino acid positions 13-28, wherein the antibody fragments are covalently attached to a polyethylene glycol (PEG) molecule.
Cette invention a pour objet un procédé de traitement, aussi bien prophylactique que thérapeutique, d'affections associées à l'activité du peptide Aß. Ce procédé emploie des fragments d'anticorps humanisés qui lient spécifiquement le peptide A.beta. humain entre les positions d'acides aminés 13 et 28, où les fragments d'anticorps sont fixés par liaison covalente à une molécule de polyéthylène glycol (PEG).
Bales Kelly Renee
Bumol Thomas Frank
Chow Chi-Kin
Demattos Ronald Bradley
Hansen Ryan John
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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