Pegylated and diglycosylated erythropoietin

Details Pegylated and diglycosylated erythropoietin Pegylated and diglycosylated erythropoietin

C - Chemistry, Metallurgy

07

K

C07K 14/505 (2006.01) A61K 38/18 (2006.01) A61K 47/48 (2006.01) C12P 21/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2460489

The invention provides an erythropoietin mutein having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells, characterized by being N-glycosylated at Asn38 but not N- glycosylated at Asn24. Such muteins have improved pharmaceutical properties.

L'invention concerne une mutéine d'érythropoïétine présentant une activité biologique in vivo provoquant une augmentation de la production des réticulocytes et des globules rouges par les cellules de la moelle osseuse. Cette mutéine se caractérise en ce qu'elle est N-glycosylée au niveau de Asn38 et de Asn83, mais qu'elle n'est pas N-glycosylée au niveau de Asn24. Les mutéines selon l'invention présentent des propriétés pharmaceutiques améliorées.

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