Pegylated factor vii glycoforms

Details Pegylated factor vii glycoforms Pegylated factor vii glycoforms

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/36 (2006.01) A61P 7/02 (2006.01) A61P 7/04 (2006.01) C07K 14/745 (2006.01) C12N 9/64 (2006.01)

Patent

CA 2490360

The invention concerns a preparation comprising a plurality of Factor VII polypeptides or Factor VII-related polypeptides, wherein the polypeptides comprise asparagine-linked and/or serine-linked oligosaccharide chains, and wherein at least one oligosaccharide group is covalently attached to at least one polymeric group. The polymeric group could be a polyalkylen oxide (PAO) e.g. polyethylene glycol (PEG).

L'invention concerne une préparation renfermant une pluralité de polypeptides du facteur VII ou des polypeptides liés au facteur VII, lesdits polypeptides contenant des chaînes d'oligosaccharides liées à la sérine et/ou à l'asparagine, et au moins un groupe d'oligosaccharides étant attaché de manière covalente à au moins un groupe polymère. Ce groupe polymère pourrait être un oxyde de polyalkylène (PAO), par exemple, un polyéthylèneglycol (PEG).

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