Pegylated factor viii

Details Pegylated factor viii Pegylated factor viii

A - Human Necessities

61

K

A61K 47/48 (2006.01) C07K 14/755 (2006.01)

Patent

CA 2647314

The invention is a proteinaceous construct comprising a Factor VIII molecule having at least a portion of the B domain intact, which is conjugated to a water-soluble polymer such as polyethylene glycol having a molecular weight of greater than 10,000 Daltons. The construct has a biological activity of at least 80% of the biological activity of native Factor VIII, and the in vivo half-life of the construct is increased by at least 1.5 fold as compared to the in vivohalf-life of native factor FVIII.

La présente invention concerne un assemblage protéinique comprenant une molécule de Facteur VIII dont au moins une partie du domaine B est intacte, conjuguée à un polymère hydrosoluble tel que le polyéthylène glycol de masse moléculaire supérieure à 10 000 Daltons. L'assemblage présente une activité biologique d'au moins 80 % en ce qui concerne l'activité biologique du Facteur VIII natif, et la demi-vie in vivo de l'assemblage est égale à au moins 1,5 fois celle du Facteur FVIII natif.

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