Pegylated insulin lispro compounds

Details Pegylated insulin lispro compounds Pegylated insulin lispro compounds

A - Human Necessities

61

K

A61K 38/28 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2727825

The present invention relates to the field of diabetes. More particularly, the invention relates to PEGylated insulin lispro compounds that are PEGylated with high molecular weight poly(ethylene glycol), are highly soluble at physiological pH, have an extended duration of action, and characterized by pharmacokinetic, pharmacodynamic, and/or activity peak-trough ratios of less than 2. The invention also relates to methods of providing such molecules, to pharmaceutical compositions containing them, and to their therapeutic uses.

La présente invention porte sur le domaine du diabète. Plus particulièrement, l'invention porte sur des composés insuliniques lispro pégylés qui sont pégylés par un poly(éthylène glycol) de masse moléculaire élevée, sont très solubles à un pH physiologique, ont une durée d'action étendue et sont caractérisés par des rapports maximum-minimum pharmacocinétiques, pharmacodynamiques et/ou d'activité inférieurs à 2. L'invention porte également sur des procédés consistant à fournir de telles molécules, sur des compositions pharmaceutiques les contenant et sur leurs utilisations thérapeutiques.

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