Pegylated interferon alfa-ccr5 antagonist combination hiv...

A - Human Necessities – 61 – K

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Details

A61K 38/21 (2006.01) A61K 31/4545 (2006.01) A61K 31/496 (2006.01) A61P 31/18 (2006.01)

Patent

CA 2365900

The use of a pegylated interferon-alfa and a CCR5 antagonist, further in association with at least one of ribavirin, IL-2, IL-12, pentafuside alone or in combination with an anti-HIV-1 drug therapy, e.g., HAART, for preparation of a medicament for the treatment of HIV-1 infections as well as HIV-1 infections as well as HIV-1 and HCV co-infections in treatment-naive as well as treatment-experienced adult and pediatric patients are disclosed.

L'invention concerne l'utilisation d'un PEG-interféron-alpha et d'un antagoniste CCR5, associés à l'un des constituants suivants: la ribavirine, IL-2, IL-12, et la pentafuside employée seule ou en combinaison avec une pharmacothérapie anti-VIH-1, par exemple HAART, ce qui permet de préparer un médicament destiné à traiter les infections à VIH-1 ainsi que les co-infections à VIH-1 et HCV, chez des patients adultes et pédiatriques soumis pour la première fois à un traitement ou ayant déjà subi un traitement.

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