Pegylated opioids with low potential for abuse

Details Pegylated opioids with low potential for abuse Pegylated opioids with low potential for abuse

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61P 25/04 (2006.01) A61P 25/36 (2006.01)

Patent

CA 2734333

The invention provides opioid agonists covalently bound to a water-soluble oligomer having reduced potential for substance abuse and uses thereof. The compounds of the invention possess altered pharmacokinetic profiles relative to the opioid agonists alone, but are not subject to the risk of physical tampering that allows for the recovery and abuse of the opioid agonist as-sociated with certain alternative delivery formulations.

L'invention concerne des agonistes d'opioïdes liés par covalence à un oligomère hydrosoluble dont le potentiel d'usage abusif de la substance est réduit et leurs utilisations. Les composés de l'invention présentent des profils pharmacocinétiques modifiés par rapport à ceux des agonistes d'opioïde seul, mais ne présentent pas de risque de falsification physique qui permettrait la récupération et l'usage abusif de l'agoniste d'opioïde associés à certaines autres formulations pour administration.

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