Pegylated recombinant human growth hormone compounds

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2721947

A chemically modified human Growth Hormone (rhGH) prepared by attaching a transient linker which comprises a polyethylene glycol. The chemically modified protein may have a much longer lasting rhGH activity than that of the unmodified rhGH, enabling reduced dose and scheduling opportunities and the modified rhGH may not cause lipoatrophy. Also includes methods of use for the treatment and/or prevention of diseases or disorders in which use of growth hormone is beneficial.

L'invention concerne une hormone de croissance humaine modifiée chimiquement (rhGH) préparée par fixation d'un lieur transitoire qui comprend un polyéthylène glycol. La protéine chimiquement modifiée peut avoir une activité rhGH durant bien plus longtemps que celle de la rhGH non modifiée, permettant des opportunités de dose réduite et de programme réduit et la rhGH modifiée ne peut pas provoquer de lipoatrophie. L'invention porte également sur des procédés d'utilisation pour le traitement et/ou la prévention de maladies ou de troubles dans lesquels l'utilisation d'hormone de croissance est utile.

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