Pegylation of polypeptides

Details Pegylation of polypeptides Pegylation of polypeptides

A - Human Necessities

61

K

A61K 47/48 (2006.01) A61K 38/16 (2006.01) C07K 14/435 (2006.01) C07K 17/08 (2006.01) C12N 9/00 (2006.01)

Patent

CA 2288429

Compounds are disclosed having the general formula R1-X-R2, wherein R1 and R2 are biologically active groups, at least one of which is polypeptidic. X is a non-peptidic polymeric group. R1 and R2 may be the same or different. Preferred R1 and R2 groups are interleukin-1 receptor antagonist, 30k Da TNF inhibitor, interleukin-2 receptors and CR1 and muteins thereof. Also included are site selectively modified interleukin-1 receptor antagonist and 30k Da TNF inhibitor.

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