A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/00 (2006.01)
Patent
CA 2575101
This invention relates to modified Vasoactive Intestinal Peptide (VIP)/Pituitary Adenylate Cyclase Activating Peptide (PACAP) Receptor 2 (VPAC2) agonists (VPAC2 agonists) comprising a VPAC2 agonist linked to a polyethylene glycol polymer, as well as related formulations, dosages, and methods of administration thereof for therapeutic purposes. These VPAC2 agonists, compositions, and methods are useful in providing a treatment option for those individuals afflicted with a metabolic disorder such as diabetes, impaired glucose tolerance, metabolic syndrome, or prediabetic states, by inducing glucose-dependent insulin secretion in the absence of the therapeutically limiting side effect of reducing or lowering blood pressure.
L'invention concerne des agonistes vis-à-vis du récepteur 2 (VPAC2) de peptide intestinal vaso-actif (VIP)/peptide d'activation d'adénylate cyclase pituitaire (PACAP) de type modifié, qui comprennent un agoniste vis-à-vis de VPAC2 lié à un polymère de polyéthylène glycol, y compris des formulations, dosages et procédés d'administration à des fins thérapeutiques. Ces agonistes, compositions et procédés sont utiles car ils offrent une possibilité de traitement aux personnes souffrant de trouble métabolique du type diabète, diminution de tolérance au glucose, syndrome métabolique ou état prédiabétique, par induction de sécrétion d'insuline qui dépend du glucose, sans effet secondaire à limitation thérapeutique entraînant une réduction ou une baisse de la pression artérielle.
Pan Clark
Whelan James
Bayer Healthcare Llc
Bayer Pharmaceuticals Corporation
Borden Ladner Gervais Llp
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