A - Human Necessities
61
K
A61K 9/20 (2006.01) A61K 9/00 (2006.01) A61K 9/02 (2006.01) A61K 9/16 (2006.01) A61K 9/46 (2006.01) A61K 9/48 (2006.01) A61K 9/50 (2006.01) A61K 9/70 (2006.01)
Patent
CA 2192086
A novel drug delivery system, e.g. in the form of a solid dosage form or a liquid formulation based on a pharmaceutical multiple unit in the form of cores such as, e.g., coated cores. The pharmaceutical formulations are based on a novel principle allowing preparation of cores such as, e.g., cores in the form of pellets, i.e. substantially spheric particles which have such a mechanical strength (expressed in terms of friability) that the cores are sufficiently robust to substantially remain intact after having been subjected to coating by standard pharmaceutical procedures well known by a person skilled in the art such as, e.g., a coating process involving a fluidized bed process. A spray-drying process for the preparation of the pharmaceutical formulation is also described.
Nouveau système de libération de médicaments sous forme solide ou liquide basé sur des unités pharmaceutiques multiples du type noyaux tels que les noyaux enrobés. Ces préparations pharmaceutiques se basent sur un nouveau principe permettant de préparer des noyaux tels que des pilules sensiblement sphériques présentant une résistance mécanique (exprimée en termes de friabilité) suffisante pour que les noyaux soient suffisamment robustes et restent pratiquement intacts après avoir subi un enrobage à l'aide de l'un des procédés courants de l'industrie pharmaceutique et bien connus des initiés tels que le lit fluidisé. Est également décrit un procédé associé de pulvérisation/séchage pour la préparation de ladite formulation pharmaceutique.
Hansen Jens
Jensen Lone Norgaard
Norling Tomas
Blake Cassels & Graydon Llp
Dumex-Alpharma A/s
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