Pellets comprising an active substance matrix resistant to...

Details Pellets comprising an active substance matrix resistant to... Pellets comprising an active substance matrix resistant to...

A - Human Necessities

61

K

A61K 9/16 (2006.01) A61K 31/522 (2006.01)

Patent

CA 2679010

The invention relates to pellets having a mean particle size of between 300 and 1100 µm, containing a pharmaceutically active substance integrated into a polymer matrix consisting of at least one water-insoluble polymer. The invention is characterised in that the polymer matrix also contains between 10 and 90 wt. % of an anionic polymer, in the release test according to USP, provided that the pellets release no more than 10 % of the active substance in the artificial gastric juice at a pH of 1.2 after 120 min, and release at least 50 % of the active substance after a total of another 300 min at a pH of 6.8 and/or 7.5.

L'invention concerne des granules présentant une granulométrie moyenne comprise entre 300 et 1100 µm et renferment une substance pharmaceutiquement active qui est intégrée dans une matrice polymère constituée d'un ou de plusieurs polymères non hydrosolubles. Cette invention est caractérisée : en ce que la matrice polymère comporte en outre entre 10 et 90 % d'un polymère anionique; et en ce que lesdits granules ne libèrent pas plus de 10 % de la substance active qu'ils contiennent dans un suc gastrique artificiel à un pH de 1,2, après 120 minutes, et en ce qu'ils ont libéré au moins 50 % de ladite substance active après encore 300 minutes à un pH de 6,8 et/ou à un pH de 7,5, dans le cadre du test de libération selon l'USP.

Affiliated with

Also associated with

Rating

Pellets comprising an active substance matrix resistant to... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pellets comprising an active substance matrix resistant to..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pellets comprising an active substance matrix resistant to... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1455545