Pellets having a core coated with an antifungal and a polymer

Details Pellets having a core coated with an antifungal and a polymer Pellets having a core coated with an antifungal and a polymer

A - Human Necessities

61

K

A61K 31/4196 (2006.01) A61K 9/50 (2006.01) A61K 31/40 (2006.01)

Patent

CA 2315110

The present invention is concerned with pellets comprising a 710-1180 µm (16-25 mesh) sugar core, a coating film of a water-soluble polymer and an antifungal agent, and a seal coating layer wherein the residual concentration of dichloromethane is below 600ppm; pharmaceutical dosage forms comprising said pellets and a method of preparing said pellets.

L'invention concerne des granules contenant un noyau glucidique de 710-1180 mu m (16-25 mesh), un film d'enrobage réalisé à partir d'un polymère soluble dans l'eau et d'un antifongique, et une couche d'enrobage étanche. La concentration résiduelle de dichlorométhane dans ledit noyau est inférieure à 600 mg/l. L'invention concerne également des formes posologiques pharmaceutiques contenant lesdits granules ainsi qu'un procédé de préparation desdits granules.

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