Penam 1,1-dioxides as beta-lactamase inhibitors

Details Penam 1,1-dioxides as beta-lactamase inhibitors Penam 1,1-dioxides as beta-lactamase inhibitors

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/00 (2006.01) C07D 205/09 (2006.01)

Patent

CA 1134349

Docket No. P.C. (Ph) 5084 PENAM 1,1-DIOXIDES AS BETA-LACTAMASE INHIBITORS ABSTRACT (3S, 5R)-Penam-3-carboxylic acid 1,1-dioxide, optionally having a methyl group at the 2-position, and esters thereof readily hydrolyzable in vivo, are useful for enhancing the effectiveness of several beta-lactam antibiotics ayainst many beta-lactamase producing bacteria.

334765

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