Penam derivatives and preparation thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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260/114.1

C07D 499/68 (2006.01)

Patent

CA 1068681

ABSTRACT OF THE DISCLOSURE Novel compounds having antibacterial properties which are of the formula Image and their pharmaceutically-acceptable salts where Z1 is Image or Image wherein Z2 is hydrogen, alkanoyl of 2 to 4 carbon atoms or alkyl- sulfonyl of 1 to 3 carbon atoms may be prepared by acylation of an amine of the formula Image or a tetrazolyl protected derivative thereof with an activated derivative of a carboxylic acid of the formula Image wherein n is 1 or 0 and if required removing the tetrazolyl pro- tecting group and if desired converting the product into a pharma- ceutically-acceptable salt.

269232

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