Penetration enhancers for transdermal delivery of systemic...

A - Human Necessities – 61 – K

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A61K 31/395 (2006.01) A61K 31/40 (2006.01) A61K 31/445 (2006.01) A61K 31/55 (2006.01) A61K 47/22 (2006.01)

Patent

CA 1306692

ABSTRACT OF THE DISCLOSURE This invention relates to a method for administering systemically active agents including therapeutic agents through the skin or mucosal membranes of humans and animals in a transdermal device or formulation comprising topically administering with said systemic agent an effective amount of a membrane penetration enhancer having the structural formula Image wherein X and Y, each, may represent sulfur, oxygen or two hydrogen atoms, A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having 1-4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkylformyl; m is 3 7; q is 2m-2x, wherein x equals the number of double bonds in the lactam ring and may be 1, 2 or 3, and R is CH3, Image or Image wherein R" is H or halogen.

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