Penicillanic acid 1,1-dioxides as .beta.-lactamase inhibitors

C - Chemistry – Metallurgy – 07 – D

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C07D 499/00 (2006.01) A61K 31/43 (2006.01) C07D 499/32 (2006.01) A61K 31/545 (2006.01)

Patent

CA 1119164

Abstract of the Disclosure Penicillanic acid l,l-dioxide, and esters thereof readily hydrolyzable in vivo, are useful as antibacterial agents, and also for enhancing the effectiveness of several .beta.-lactam antibiotics against many .beta.-lactamase producing bacteria. Derivatives of penicillanic acid l,l-dioxide having the carboxy group protected by a conventional penicillin carboxy protecting group are useful intermediates to penicillanic acid l,l-dioxide. Penicillanic acid l-oxides and certain esters thereof are useful chemical intermediates to penicillanic acid l,l-dioxide and its esters.

304796

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