Penicillin crystal and process for producing the same

Details Penicillin crystal and process for producing the same Penicillin crystal and process for producing the same

C - Chemistry, Metallurgy

07

D

C07D 499/00 (2006.01)

Patent

CA 2540603

2.beta.-chloromethyl-2.alpha.-methylpenam-3.alpha.-carboxylic acid benzhydryl ester (CMPB) crystals having excellent stability; and a process for producing CMPB crystals which comprises (A) the step of concentrating a CMPB-containing solution, (B) the step of subjecting the resultant concentrate to column chromatography, (C) the step of concentrating a CMPB-containing fraction, and (D) the step of dissolving the resultant CMPB-containing concentrate in an ether solvent and subsequently adding a hydrocarbon solvent to this solution to precipitate CMPB crystals.

Cette invention se rapporte à des cristaux de benzhydryl-ester d'acide 2.beta.-chlorométhyl-2.alpha.-méthylpénam-3.alpha.-carboxylique (CMPB) ayant une excellente stabilité; à un procédé de production de ces cristaux de CMPB qui consiste: (A) à concentrer une solution contenant du CMPB, (B) à soumettre le concentré qui en résulte à une opération de chromatographie sur colonne, (C) à concentrer une fraction contenant du CMPB, et (D) à dissoudre le concentré contenant du CMPB qui en résulte dans un solvant à base d'éther et à ajouter ensuite un solvant à base d'hydrocarbures à cette solution, pour précipiter les cristaux de CMPB.

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