Penicillin crystal and process for producing the same

Details Penicillin crystal and process for producing the same Penicillin crystal and process for producing the same

C - Chemistry, Metallurgy

07

D

C07D 499/18 (2006.01) A61K 31/431 (2006.01) A61P 31/04 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01) C07D 499/87 (2006.01)

Patent

CA 2386083

Crystals of 2-methyl-2-triazolylmethylpenam-3-carboxylic acid 1,1-dioxide diphenylmethyl ester. Even when allowed to stand for 1 year at 5 to 35~C, the crystals are stable and undergo substantially no decomposition or alteration. The crystals are produced by adding 2-methyl-2-triazolylmethylpenam-3- carboxylic acid 1,1-dioxide diphenylmethyl ester, represented by the formula (1), (1) (wherein Ph represents phenyl) in an oily state or amorphous powdery state or an organic solvent solution of the ester to at least one member selected among alcohols and ketones and crystallizing the 2-methyl-2- triazolylmethylpenam-3-carboxylic acid 1,1-dioxide diphenylmethyl ester.

L'invention concerne des cristaux de 2-méthyl-2- triazolylméthylpenam-3-acide carboxylique 1, 1-dioxyde diphénylméthyl ester. Même lorsqu'ils sont exposés pendant un an à des températures comprises entre 5 et 35·, les cristaux sont stables et ne se décomposent pas ou ne s'altèrent pas. On produit les cristaux en ajoutant 2-méthyl-2- triazolylméthylpenam-3-acide carboxylique, 1-dioxyde diphénylméthyl ester, représentés par la formule (1) (dans laquelle Ph représente le phényle) dans une solution d'ester à solvant organique ou à état pulvérulent amorphe ou à état huileux, à au moins un élément sélectionné parmi des alcools et des cétones, et en cristallisant 2-méthyl-2- triazolylméthylpenam-3-acide carboxylique, 1-dioxyde diphénylméthyl ester.

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