C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/118
C07D 499/42 (2006.01) C07C 51/31 (2006.01) C07D 307/88 (2006.01) C07D 317/58 (2006.01) C07D 333/72 (2006.01) C07D 499/00 (2006.01)
Patent
CA 1131620
ABSTRACT OF THE DISCLOSURE This invention relates to the phthalide ester of 6-[D(-).alpha.- aminophenylacetamido] penicillanic acid and its pharmaceutically acceptable acid addition salts, and to a process for its preparation. The esters of the invention are novel and are useful in that they produce high serum concentrations of the parent penicillin when ad- ministered orally, and higer than can be achieved with the parent penicillin itself. The esters of the present invention may be pre- pared by a process which comprises reacting 6-aminopenicillanic acid phthalide ester or a silyl derivative thereof with a reactive N- acylating derivative of the (D) isomer of a compound of the formula: Image wherein X is an amino group, a protected amino group or a group which is convertible to an amino group, removing the silyl group, if present, by hydrolysis or alcoholysis, and if X is not an amino group, converting it to such a group under neutral or acid conditions. 6-aminopenicillanic acid phthalide ester is a novel compound and its preparation is also dis- disclosed as well as salts of this compound.
393922
Clayton John P.
Ferres Harry
Beecham Group Limited
Borden Ladner Gervais Llp
LandOfFree
Penicillins and cephalosporins does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Penicillins and cephalosporins, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Penicillins and cephalosporins will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-701177