Penicillins and cephalosporins and their production

Details Penicillins and cephalosporins and their production Penicillins and cephalosporins and their production

C - Chemistry, Metallurgy

07

D

260/104.3, 260/1

C07D 499/04 (2006.01) C07D 499/00 (2006.01) C07D 501/04 (2006.01)

Patent

CA 1040622

Abstract of the Disclosure .beta.-Lactams of the formula Image and pharmaceutically acceptable nontoxic salts thereof wherein A is hydrogen or alkyl of 1 to 4 carbon atoms; B is phenyl, methylphenyl, chlorophenyl, hydroxyphenyl or cyclohexa-1,4-dien-1-yl; R is a moiety of the formula Image or Image wherein E is hydrogen, -OH or -O-CO-CH3; and ? constitutes a center of chirality; are produced which exhibit antibiotic activity. These .beta.-lactams exhibit a substantially greater anti- bacterial action, especially against Enterobacterisceae than known .beta.-lactams.

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