Penicillins and processes for their preparation and use

Details Penicillins and processes for their preparation and use Penicillins and processes for their preparation and use

C - Chemistry, Metallurgy

07

D

260/114.3

C07D 499/70 (2006.01) C07D 233/32 (2006.01) C07D 233/38 (2006.01) C07D 499/00 (2006.01)

Patent

CA 1070674

Abstract 6-[.alpha.-(Imidazolidin-2-on-1-carbonylamide)acet- amido]-penicillanic acids substituted in the 3-position of the imidazolidinone ring with phenyl or a substituted phenyl group and on the .alpha.-carbon atom of the acetamido bridge with a phenyl, thienyl, cyclohexenyl or cyclohexadienyl group, and their salts, are prepared by treatment of the corresponding 6-(.alpha.-aminoacetamido)penicillanic acid with a 3-substituted-imidazolidin-2-one-1-carboxylic acid deri- vative. The compounds, of which .alpha.-(3-phenylimidazolidin- 2-on-1-ylcarbonylamino)benzylpenicillin is a representative example, are antibacterial agents.

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