Pentacyclic compounds

Details Pentacyclic compounds Pentacyclic compounds

C - Chemistry, Metallurgy

07

D

260/239.1, 260/2

C07D 487/04 (2006.01) C07D 223/14 (2006.01) C07D 223/32 (2006.01) C07D 241/38 (2006.01) C07D 487/06 (2006.01)

Patent

CA 1196328

ABSTRACT Compounds of formula (I), (I) Image or an N-oxide or pharmaceutically acceptable salt thereof, wherein R1 is hydrogen, C1-7 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl or C1-4 alkyl substituted by C2-7 alkenyl, C2-7 alkynyl, C3-7 cycloalkyl, hydroxy, thiol, C1-4 alkoxy, C1-4 alkylthio, carboxy, C1-4 alkoxycarbonyl, C1-4 alkanoyl, amino optionally substituted by one or two C1-4 alkyl or by C4-6 polymethylene optionally containing an oxygen or nitrogen atom, aminocarbonyl optionally N-substituted by one or two C1-4 alkyl, or benzoyl or phenyl either being optionally ring-substituted by C1-4 alkyl, C1-4 alkoxy, halogen or trifluoromethyl, R2 and R3 are the same or different and are hydrogen, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, halogen or trifluoromethyl, m is 1 to 3 and n is 1 or 2, the hydrogen atom bonded to the Ca carbon atom being trans to the hydrogen atom bonded to the Cb carbon atom, having mood-modifying activity such as anti-depressant activity.

422816

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