C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/238.1, 260/2
C07D 487/16 (2006.01) C07D 223/20 (2006.01) C07D 267/20 (2006.01) C07D 471/16 (2006.01) C07D 487/04 (2006.01) C07D 498/04 (2006.01) C07D 498/16 (2006.01) C07D 513/16 (2006.01)
Patent
CA 1167439
ABSTRACT OF THE DISCLOSURE Compounds of formula (I): Image (I) wherein: X is CH2, O, S or NR wherein R is hydrogen or C1-4 alkyl; Y and Z are independently selected from hydrogen, C1-4 alkyl, C1-4 alkoxy, halogen or CP3; R1 is hydrogen, C1-6 alkyl, phenyl or phenyl-C1-4 alkyl any of which phenyl moieties may be substituted by one or more of C1-6 alkyl, C1-6 alkoxy, halogen or CF3; R2 is hydrogen, OH, C1-6 alkoxy, phenyl-C1-4 alkoxy, C1-7 acyloxy or NR4R5 wherein R4 and R5 are independently selected from hydrogen or C1-6 alkyl; R4 is hydrogen and R5 i8 OH or C1-4 alkoxy; or R4 and R5 together from C3-6 polymethylene optionally inter- rupted by O or NR6 where R6 is hydrogen or C1-4 alkyl; or together with R1 forms an oxo group or =NOR7 wherein R7 is hydrogen or C1-6 alkyl; and R3 is hydrogen or C1-6 alkyl, have anti-depressant and/or anxiolytic activity, processes for their preparation and their use.
393370
Gardner Derek V.
Gaster Laramie M.
Beecham Group Limited
Borden Ladner Gervais Llp
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