Pentaerythritol lipid derivatives

Details Pentaerythritol lipid derivatives Pentaerythritol lipid derivatives

C - Chemistry, Metallurgy

12

N

C12N 15/88 (2006.01) A61K 9/127 (2006.01) A61K 31/70 (2006.01) A61K 47/44 (2006.01) A61K 48/00 (2006.01) C07C 31/24 (2006.01) C07C 219/04 (2006.01) C07C 229/08 (2006.01) C07C 229/12 (2006.01) C07D 209/20 (2006.01) C07H 21/00 (2006.01)

Patent

CA 2325849

This invention relates to pentaerythritol lipid derivatives which are useful for the intracellular delivery of polynucleotides. These cationic lipids are useful in the preparation of liposomes and other lipid vesicles for the delivery of nucleic acids into mammalian cells.

L'invention a trait à des dérivés de lipides de pentaérythritol qui sont utiles pour l'administration intracellulaire de polynucléotides. Ces lipides cationiques sont utiles dans la préparation de liposomes et d'autres vésicules lipidiques en vue de l'administration d'acides nucléiques dans des cellules de mammifère.

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