C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 381/00 (2006.01) A01N 1/02 (2006.01) A61K 31/155 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2536459
The invention relates to pentafluorosulfanyl phenyl-substituted benzoylguanidines of formulas I and II, wherein R1, R1', R2, R2', R3, R3', R4 and X are defined as cited in the claims. Said compounds are suitable for use as anti-arrhythmic medicaments with a cardio-protective component for the treatment and prophylaxis of infarcts and for the treatment of angina pectoris. They also preventively inhibit the pathophysiological processes that occur during damage resulting from ischaemia, in particular the triggering of cardiac arrhythmia resulting from ischaemia.
L'invention concerne des benzoylguanidines à substitution pentafluorosulfanylphényle de formules (I) et (II) dans lesquelles R1, R1', R2, R2', R3, R3', R4 et X ont la signification indiquée dans les revendications. Lesdits composés sont conçus pour servir de médicaments anti-arythmiques à composante cardioprotectrice destinés à prevenir et à traiter un infarctus, ainsi qu'à traiter une angine de poitrine. Les composés selon l'invention inhibent également de manière préventive des processus pathophysiologiques lors de l'apparition de lésions induites par ischémie, notamment lors du déclenchement d'arythmies cardiaques induites par ischémie.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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