C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 381/00 (2006.01) A61K 31/155 (2006.01) A61P 7/04 (2006.01) A61P 9/06 (2006.01) A61P 25/24 (2006.01) A61P 33/06 (2006.01)
Patent
CA 2580132
The invention relates to pentafluorosulfanylphenyl-substituted benzoylguanidines, to a method for the production thereof, to their use as a medicament or diagnostic agent, and to a medicament containing these compounds. These pentafluorosulfanylphenyl-substituted benzoylguanidines are of formula (I), in which R1 to R5 have the meanings as cited in the claims, and are, for example, suited for use as antiarrhythmic medicaments with a cardioprotective constituent for preventing infarcts, treating infarcts and for treating angina pectoris. These compounds inhibit, even preventively, the pathophysiological processes in the occurrence of ischemically induced damages, particularly during the initiation of ischemically induced cardiac arrhythmias.
La présente invention concerne des benzoylguanidines substituées par pentafluorsulfanylphényle, ayant la formule (I) dans laquelle R1 à R5 ont les correspondances indiquées dans les revendications. Ces composés conviennent par exemple à l'utilisation en tant qu'agents pharmaceutiques anti-arythmie comprenant une composante cardio-protectrice pour prévenir et traiter l'infarctus, et traiter l'angine de poitrine. Ces composés inhibent également de façon préventive les processus patho-physiologiques lors de l'apparition de dommages d'origine ischémique, en particulier lors du déclenchement d'arythmies cardiaques d'origine ischémique.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Sanofi-Aventis Deutschland Gmbh
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