Pentamidine solution with neutral ph and method for...

A - Human Necessities – 61 – K

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A61K 31/155 (2006.01)

Patent

CA 2057834

- 8 - ABSTRACT A small volume aqueous solution of pentamidine or a pharmaceutically acceptable salt thereof having a pH of about 6.5 to about 7.5 and a method for its administration. The concentration of the pentamidine in the solution is in the range of about 0.001 to about 150 mg/ml. The pentamidine solution is administered by mixing either lyophilized pentamidine or a low pH solution of pentamidine with a solution of sufficient pH and volume to impart a pH of about 6.5 to about 7.5 to the mixture. The pentamidine concentration in the mixture is about 100 mg/ml. The mixture is then administered to a patient either intravenously, intramuscularly or nebulized and inhaled by the patient.

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